BOPI 10 BR/2023 REPERTOIRE NUMERIQUE 25 shoulder (7) that axially separates the spigot (5) and the central rod portion (2), wherein the female end (4) comprises a sleeve portion (8) configured to fit to the spigot (5), wherein the base (6) is provided with an outer thread and wherein the sleeve portion (8) is provided with an inner thread, wherein the inner thread corresponds to the outer thread such that the inner thread of the sleeve portion (8) is attachable to the outer thread of the base (6) of the spigot (5) of a further drill string rod (1 b) of the assembly (10), wherein, in a radial plane (P) to the longitudinal axis (9) of the drill string rod (1), the base (6) of the spigot (5) is defined by an outer third diameter (Dspigot) and an inner fourth diameter (dspigot) and the sleeve portion (8) is defined by an outer fifth diameter (Dsleeve) and an 20 inner sixth diameter (dsleeve), wherein the second diameter (Drod) is between 30 and 60 mm, and wherein the six diameters mentioned are selected within specific constraints. Consulter le mémoire (11) 21204 (51) A61K 31/427 (2018.01); A61P 7/00 (2018.01); C07D 417/04 (2018.01); C07D 417/14 (2018.01) (21) 1202300101 - PCT/US2021/050216 (22) 14/09/2021 (30) US n° 63/077,973 du 14/09/2020 (54) Compounds as modulators of bisphosphoglycerate mutase for the treatment of sickle cell disease. (72) MUNSON, Mark (US); DESAI, Kunal (US); FANG, Zhong (US); HONG, Vu (US); JIANG, John Ziqi (US); LIM, Sungtaek (US); LIU, Jinyu (US) et GUERTIN, Kevin (US) (73) GENZYME CORPORATION, 50 Binney Street, CAMBRIDGE, Massachusetts 02142 (US) (74) S.C.P AKKUM, AKKUM & Associates, n° 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo, B.P. 4966, YAOUNDE (CM). (57) Provided herein are compounds and compositions thereof for modulating bis-phosphoglycerate mutase (BPGM) for treating sickle cell disease. Formula I Consulter le mémoire ________________________________________ (11) 21205 (51) A61K 31/439 (2018.01); A61P 3/00 (2018.01); A61P 37/00 (2018.01); A61P 7/06 (2018.01); C07D 471/08 (2018.01);
RkJQdWJsaXNoZXIy MTM1NDc3MA==