BOPI 10 BR/2023 REPERTOIRE NUMERIQUE 26 C07D 471/18 (2018.01); C07D 471/22 (2018.01) (21) 1202300104 - PCT/US2021/050212 (22) 14/09/2021 (30) US n° 63/078,118 du 14/09/2020; US n° 63/229,338 du 04/08/2021 (54) Tetrahydroisoquinoline derivatives for the treatment of red blood disorders and inflammatory diseases. (72) BARBERIS, Claude (US); KARAGEORGE, George (US); JURCAK, John (US) et TERRANOVA, Kristen (US) (73) SANOFI, 46 avenue de la Grande Armée, 75017 PARIS (FR) (74) S.C.P AKKUM, AKKUM & Associates, n° 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo, B.P. 4966, YAOUNDE (CM). (57) Provided herein are compounds and compositions thereof for activating nuclear factor erythroid - related factor 2 (Nrf2) for treating red blood cell diseases and inflammatory diseases. Formula I Consulter le mémoire ________________________________________ (11) 21206 (51) E21B 33/124 (2018.01); E21B 37/08 (2018.01) (21) 1202300105 - PCT/EP2021/075698 (22) 17/09/2021 (30) EP n° 20306046.2 du 17/09/2020 (54) Well regenerating apparatus and method. (72) JIMENEZ MARTINEZ, Alberto (ES) et DE CAMPO CASTAÑEDA, Lino (ES) (73) SUEZ INTERNATIONAL, Tour CB21, 16 Place de l’Iris, 92040 PARIS La Défense (FR) (74) S.C.P AKKUM, AKKUM & Associates, n° 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo, B.P. 4966, YAOUNDE (CM). (57) A well regenerating apparatus comprising : a treatment device (41), arranged to regenerate a well screen (WS) in a treatment zone of the well screen (WS), at least an upper packer (31) and a lower packer (32) arranged to isolate the treatment zone between the upper packer (31) and the lower packer (32), characterized in that the well regenerating apparatus comprises a sliding sleeve (20), moveable between : - a lifting position in which the sliding sleeve (20) is connected to both the upper packer (31) and the lower packer (32), - a treatment position, in which the sliding sleeve (20) is disconnected at least from one of the upper packer (31) and the lower packer (32), so as to allow the treatment device (41) to face directly the well screen (WS).
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