BOPI 11 BR/2023 REPERTOIRE NUMERIQUE 16 (73) OSE Immunotherapeutics, 22, boulevard Benoni Goullin, 44200 NANTES (FR) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS SARL, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, B.P. 8211, YAOUNDE (CM). (57) The present invention provides humanized antiCMKLR 1 compounds having an agonist capability on the interaction between Resolvin E1 and CMKLR1, and their uses for treating or preventing a disease, in particular wherein the resolution of inflammation is delayed or disrupted. Fig. 20 Consulter le mémoire ________________________________________ (11) 21240 (51) A61K 31/554 (2018.01); A61P 5/00 (2018.01) ; C07D 281/10 (2018.01) (21) 1202200214 - PCT/EP2020/084567 (22) 04/12/2020 (30) IN n° 201911049982 du 04/12/2019 (54) Benzothia(di)azepine compounds and their use as bile acid modulators. (72) GILLBERG, Per-Göran (SE); STARKE, Ingemar (SE) et KULKARNI, Santosh S. (IN) (73) ALBIREO AB, Arvid Wallgrens backe 20, 413 46 GÖTEBORG (SE) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS SARL, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, B.P. 8211, YAOUNDE (CM). (57) The invention relates to 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases. Fig. 1 Ex 3 Consulter le mémoire ________________________________________ (11) 21241 (51) A61K 31/443 (2018.01); A61P 29/00 (2018.01); C07D 405/12 (2018.01) ; C07D 405/14 (2018.01) (21) 1202200220 - PCT/US2020/063290 (22) 04/12/2020 (30) US n° 62/944,869 du 06/12/2019 (54) Substituted tetrahydrofurans as modulators of sodium channels. (72) SCHMIDT, Yvonne (US); HURLEY, Dennis James (US); DURRANT, Steven John (US); AHMAD, Nadia (US); BECK, Elisabeth Mary (US); CARVALHO MEIRELES, Lidio (US); CHUDYK, Ewa Iwona (US);
RkJQdWJsaXNoZXIy MTM1NDc3MA==