BOPI 11 BR/2023 REPERTOIRE NUMERIQUE 17 ETXEBARRIA JARDI, Gorka (US); GALAN, Bhairavi (US); HADIDA RUAH, Sara S. (US); KNEGTEL, Ronald Marcellus (US); NEUBERT, Timothy Donald (US); PINDER, Joanne Louise (US); PONTILLO, Joseph (US); PULLIN, Robert (US); SHAW, David Matthew (US); SKERRATT, Sarah (US); STAMOS, Dean (US); THOMSON, Stephen Andrew (US); VIRANI, Anisa Nizarali (US) et WRAY, Christopher (US) (73) VERTEX PHARMACEUTICALS INCORPORATED, 50 Northern Avenue, BOSTON, Massachusetts 02210 (US) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS SARL, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, B.P. 8211, YAOUNDE (CM). (57) Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain. Fig. 11 Consulter le mémoire (11) 21242 (51) B01D 3/08 (2018.01); B01F 7/00 (2018.01); B01F 7/04 (2018.01); F26B 11/12 (2018.01) ; F26B 17/00 (2018.01) (21) 1202200222 - PCT/EP2020/085337 (22) 09/12/2020 (30) EP n° 19214531.6 du 09/12/2019 (54) Method for continuous thermal separation of a multi-component substance. (72) HELLENES, Agnar (NO) (73) HELLENES, Holding AS, Rusta 14 , N-6810 FØRDE (NO) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS SARL, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, B.P. 8211, YAOUNDE (CM). (57) The invention concerns a method for continuous thermal separation of a substance being fed into a treatment chamber within a vessel. Besides the vessel, the apparatus comprises a heating device with an external heat source and a rotary mechanism with an external rotary drive. The heating device and the rotary drive are mutually operated such that a resulting operational temperature Top is obtained within a volume Vp near an inner surface of the vessel which is equal or higher than an evaporation temperature Te of at least one liquid constituting part of the substance.
RkJQdWJsaXNoZXIy MTM1NDc3MA==