BOPI 11 BR/2023 REPERTOIRE NUMERIQUE 18 Consulter le mémoire ________________________________________ (11) 21243 (51) A61K 31/453 (2018.01); A61K 31/496 (2018.01) ; A61P 25/28 (2018.01) (21) 1202200229 - PCT/NL2020/050782 (22) 11/12/2020 (30) NL n° 2024431 du 11/12/2019 (54) Compounds for treatment of alzheimer's disease. (72) HENNING, Robert Henk (NL); VAN DER GRAAF, Adrianus Cornelis (NL); KRENNING, Guido (NL); SWART, Daniël Henri (NL); DE VEIJMESTDAGH, Christina Françoise (NL) et VOGELAAR, Pieter Cornelis (NL) (73) 1-SULFATEQ B.V., Admiraal de Ruyterlaan 5a, 9726 GN GRONINGEN (NL) et 2-RIJKSUNIVERSITEIT GRONINGEN, Broerstraat 5, 9712 CP GRONINGEN (NL) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS SARL, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, B.P. 8211, YAOUNDE (CM). (57) The invention relates to certain chromanol, quinone or hydroquinone compounds and derivatives thereof for treatment of Alzheimer's disease and/or for improving memory function and/or reducing plaque load. Specifically, the present invention relates to chromanol compounds chosen from (6-hydroxy-2,5,7,8tetramethylchroman-2yl)(piperazin-1-yl)methanone, ((S)-6-hydroxy-2,5,7,8-tetramethyl-N-((R)- piperidin-3-yl)chroman-2-carboxamide hydrochloride and S-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)(4-(2-hydroxyethyl)piperazin-1-yl) methanone, and pharmaceutically acceptable salts thereof. Fig. 1 Consulter le mémoire ________________________________________ (11) 21244 (51) A01G 13/10 (2018.01) ; A01N 47/00 (2018.01) (21) 1202200254 (22) 17/06/2022 (54) Produit à base des feuilles de Kalanchoe tubiflora permettant de protéger les cultures végétales contre les ruminants (bovins, ovins, caprins). (72) VODJI Gratien (BJ) et AGBANGBA Codjo Emilie (BJ)
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