BOPI 02 BR/2023 REPERTOIRE NUMERIQUE 12 HENNESSY, Emma Elizabeth Clare (GB); LAUTE-CALY, Delphine Louise Claudette (GB); COWIE, Philip (GB); RAFTIS, Emma (AE); COUTURIER-MAILLARD, Aurélie Pascale Patricia (GB); DELDAY, Margaret Inkster (GB); ADRIANI, Marsilio (GB) et CHRISTOFI, Maria (GB) (73) 4D Pharma Research Limited, Life Sciences Innovation Building, Cornhill Road, ABERDEEN Aberdeenshire AB25 2ZS (GB) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS Sarl, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) The invention provides compositions comprising bacterial strains for stimulating the immune system and treating and preventing diseases. Fig. 23 Consulter le mémoire (11) 20783 (51) A61K 31/01 (2018.01); A61K 47/22 (2018.01) ; A61K 47/24 (2018.01) (21) 1202000394 - PCT/US2019/030625 (22) 03/05/2019 (30) US n° 62/666,699 du 03/05/2018; US n° 62/809,123 du 22/02/2019 (54) Carotenoid compositions and uses thereof. (72) NIYIKIZA, Clet (US); MOYO, Victor, Mandla (US); GENG, Bolin (US); XU, Zhenghong (US); KHALIFA, Kaniz (US) et KIM, Gwangseong (US) (73) L.E.A.F. Holdings Group LLC, 326 Overlook Lane, GULPH MILLS, PA 19428 (US) (74) S.C.P AKKUM, AKKUM & Associates, No. 1777, Rue 6.261, Yaoundé, Auditorium Jean Paul II, Quartier Mbankolo, B.P. 4966, YAOUNDE (CM). (57) Provided herein are pharmaceutical compositions comprising carotenoids, including liposomes that encapsulate carotenoids including ionizable carotenoids such as trans-crocetin. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, delivering, and using the pharmaceutical compositions are also provided.
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