BOPI 02 BR/2023 REPERTOIRE NUMERIQUE 13 Fig. 3 Consulter le mémoire ________________________________________ (11) 20784 (51) A61K 31/397 (2018.01); A61P 25/18 (2018.01); C07D 471/04 (2018.01); C07D 491/107 (2018.01) (21) 1202100015 - PCT/IB2019/055948 (22) 12/07/2019 (30) HU n° P1800248 du 13/07/2018 (54) Spirochromane derivatives. (72) ÉLES, János (HU); NÉMETHY, Zsolt (HU); DUDÁSNÉ MOLNÁR, Katalin (HU); LEDNECZKI, István (HU); TAPOLCSÁNYI, Pál (HU); HORVÁTH, Anita (HU) et LÉVAY, György István (HU) (73) Richter Gedeon Nyrt., Gyömröi út 19-21., 1103 BUDAPEST (HU) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS Sarl, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) The invention relates to spirochromane derivatives, or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof, as well as to pharmaceutical compositions containing them and to their use as modulators of a7 nicotinic acetylcholine receptor activity in a mammalian subject. Formula I & Fig. 1 Consulter le mémoire ________________________________________ (11) 20785 (51) A61K 31/54 (2018.01); A61P 25/18 (2018.01); C07D 285/16 (2018.01); C07D 417/04 (2018.01); C07D 417/12 (2018.01); C07D 471/04 (2018.01) (21) 1202100016 - PCT/IB2019/055949 (22) 12/07/2019 (30) HU n° P1800249 du 13/07/2018 (54) Thiadiazine derivatives. (72) LEDNECZKI, Istvan (HU); NÉMETHY, Zsolt (HU); ÉLES, János (HU); GÁBOR, Eszter (HU); PETRO,József Levente (HU); SELÉNYI, György (HU); TAPOLCSÁNYI, Pál (HU); LÉVAY, György István (HU); VISEGRÁDI, András (HU) et JABLONKAI, Erszébet (HU) (73) Richter Gedeon Nyrt., Gyömröi út 19-21, 1103 BUDAPEST (HU) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS Sarl, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) The invention relates to thiadiazine derivatives, or pharmaceutical acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and
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