BOPI 05 BR/2023 REPERTOIRE NUMERIQUE 12 CLEVELAND, Thomas (US); CONROY, Erica (US); COON, Timothy Richard (US); FRIEMAN, Bryan A. (US); GROOTENHUIS, Peter Diederik Jan (US); GROSS, Raymond Stanley (US); HARIPADA, Khatuya (US); JOSHI, Pramod Virupax (US); KRENITSKY, Paul John (US); LIN, Chun-Chieh (US); MARELIUS, Gulin Erdogan (US); MELILLO, Vito (US); MCCARTNEY, Jason (US); NICHOLLS, Georgia McGaughey (US); PIERRE, Fabrice Jean Denis (US); SILINA, Alina (US); UY, Johnny (US) et ZHOU, Jinglan (US) (73) Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, 15th Floor, BOSTON, 02210, Massachusetts (US) (74) SPOOR & FISHER Inc. NGWAFOR & PARTNERS Sarl, The House of Gideon, Golf/Bastos Quarters, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) The present invention features a compound of formula (I): (I) or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof. Formula (I) Consulter le mémoire ________________________________________ (11) 20933 (51) A23L 7/161 (2018.01); A23P 20/10 (2018.01) (21) 1201700466 - PCT/ES2016/070340 (22) 04/05/2016 (30) ES n° P2015306021 du 07/05/2015 (54) Improvements to patent P201231330 "method for the treatment of corn kernels intended for the production of popcorn using microwave appliances, and resulting product. (72) GALCERAN MARTORELL Carlos (ES) (73) LIVEN, S.A.U, Alcalde Ramón Escayola, 66, 08197 VALLDOREIX (ES) (74) Cabinet DZOUPET Innocent, B.P. 15346, YAOUNDE (CM). (57) In the method of the main patent, corn kernels coated with sunflower lecithin and additives are obtained. According to the improvements, the additives and sunflower lecithin can be added in liquid state, solid state or both, and can be mixed and subsequently filtered before reaching a final mixer (2) to which are added not only the additives and sunflower lecithin, in any state, but also the corn kernels (1), in order to coat the corn kernels inside the mixer. The improvements also provide for the substitution of sunflower lecithin by other compounds with which similar results can be obtained, such as fructose syrup, liquid glucose, corn syrup, molasses, inverted sugar syrup or cornstarch, the kernels obtained being able to be coated with more than one coating of a different nature.
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