BOPI 05 BR/2023 REPERTOIRE NUMERIQUE 13 Consulter le mémoire ________________________________________ (11) 20934 (51) A61K 31/4985 (2018.01); A61K 31/5377 (2018.01); A61K 9/00 (2018.01) (21) 1201800052 (22) 08/02/2018 (30) US n° 61/920, 407 du 23/12/2013 (54) Syk inhibitors. (72) LEE Seung H. (US); CURRIE Kevin S. (US); LO Jennifer R. (US); BLOMGREN Peter A. (US) et KROPF Jeffrey E. (US) (73) GILEAD SCIENCES, INC., 333 Lakeside Drive, FOSTER CITY, CA 94404 (US) (74) GAD CONSULTANTS SCP, B.P. 13448, YAOUNDE (CM). (57) The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I: Formula I wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk. Consulter le mémoire ________________________________________ (11) 20935 (51) C10G 31/06 (2018.01); C10G 9/36 (2018.01) ; C10G 9/42 (2018.01) (21) 1202000212 - PCT/US2018/067062 (22) 21/12/2018 (30) US n° 62/609,732 du 22/12/2017 (54) Methods for processing hydrocarbon feedstocks. (72) SWISS, Gerald F. (US); MILLER, Robert PW (US) et FALCONER, Ross Alan (US) (73) NexCrude Technologies, Inc, P.O. Box 233, DENNIS, MA 02641 (US)
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