BOPI 06 BR/2023 REPERTOIRE NUMERIQUE 16 RAHL, Peter (US) et ZHOU, Feng (CA) (73) Fulcrum Therapeutics, Inc., 26 Landsdowne Street, CAMBRIDGE, Massachusetts 02139 (US) (74) Cabinet Spoor & Fisher Inc. Ngwafor & Partners, The House of Gideon, Golf/Bastos Quarter, Opposite The American Embassy, Entrance-Saint John Paul, II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula I: or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein. Formula I Consulter le mémoire (11) 20990 (51) E04B 2/96 (2018.01) (21) 1202100430 - PCT/IB2020/052277 (22) 13/03/2020 (30) US n° 62/818,821 du 15/03/2019; BE n° 2019/5399 du 19/06/2019 (54) Curtain wall. (72) CLAEYS, Eric (BE) (73) 1-CLAEYS, Stephanie Catharina R., Theo De Belderlaan 4, 2240 ZANDHOVEN (BE); 2-CLAEYS, Laurens Léonard J., Theo De Belderlaan 4, 2240 ZANDHOVEN (BE) et 3-CLAEYS, Nausikaä Els P., Theo De Belderlaan 4, 2240 ZANDHOVEN (BE) (74) Cabinet Spoor & Fisher Inc. Ngwafor & Partners, The House of Gideon, Golf/Bastos Quarter, Opposite The American Embassy, Entrance-Saint John Paul, II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) A curtain wall that comprises one or more mullions (2) and one or mote transoms (3) and panels (4-4A) that are fined with their edges (5) at least in the mullions (2) and optionally in the transoms (3). characterized in that the aforementioned mullion is assembled from at least an inner profile (2C) and an outer profile (2A) joined together by means of one or more plastic profiles (2B). wherein at least the inner profile (2C) consists substantially of steel.
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