BOPI 06 BR/2023 REPERTOIRE NUMERIQUE 17 Fig. 11 Consulter le mémoire ________________________________________ (11) 20991 (51) A61K 31/58 (2018.01); A61P 25/00 (2018.01); C07J 1/00 (2018.01); C07J 43/00 (2018.01); C07J 5/00 (2018.01); C07J 51/00 (2018.01); C07J 7/00 (2018.01); C07J 71/00 (2018.01); C07J 9/00 (2018.01) (21) 1202100541 - PCT/US2020/035210 (22) 29/05/2020 (30) US n° 62/855, 435 du 31/05/2019 (54) Neuroactive steroids and compositions thereof. (72) SALITURO, Francesco G. (US); BLANCO-PILLADO, Maria Jesus (US) et MORNINGSTAR, Marshall Lee (US) (73) SAGE THERAPEUTICS, INC., 215 First Street, CAMBRIDGE, MA 02142 (US) (74) Cabinet Spoor & Fisher Inc. Ngwafor & Partners, The House of Gideon, Golf/Bastos Quarter, Opposite The American Embassy, Entrance-Saint John Paul, II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7a, R7a, R11a, R11b, R12a, R12b, R16a, R16b, R19, R11a, R22, RX, RY and n are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders. Formula I Consulter le mémoire ________________________________________ (11) 20992 (51) A47J 36/24 (2018.01) (21) 1202100597 - PCT/EP2020/065087 (22) 29/05/2020 (30) DE n° 10 2019 118 098.8 du 04/07/2019; DE n° 10 2019 128 375.2 du 21/10/2019 (54) Portable heat source. (72) KRAFT, Werner (DE); LANZ, Tim (DE); VETTER, Peter (DE) et STAHL, Veronika (DE) (73) Deutsches Zentrum für Luft- und Raumfahrt e.V., Linder Höhe, KÖLN 51147 (DE) (74) S.C.P AKKUM, AKKUM & Associates, No. 1777, rue 6.261, Yaoundé, Auditorium Jean
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