BOPI 06 BR/2023 REPERTOIRE NUMERIQUE 23 Fig. 5 Consulter le mémoire ________________________________________ (11) 21000 (51) A61K 31/437 (2018.01); A61K 31/44 (2018.01); A61K 31/4725 (2018.01); A61K 31/519 (2018.01); C07D 217/04 (2018.01); C07D 401/14 (2018.01); C07D 471/04 (2018.01) ; C07D 487/04 (2018.01) (21) 1202200233 - PCT/US2020/064765 (22) 14/12/2020 (30) US n° 62/949,245 du 17/12/2019; US n° 62/949,248 du 17/12/2019; US n° 63/025,629 du 15/05/2020 (54) PRMT5 inhibitors. (72) MACHACEK, Michelle (US); ALTMAN, Michael D. (US); HUANG, Chunhui (US); REUTERSHAN, Michael H. (US); SLOMAN, David L. (US); WITTER, David J. (CA) et GIBEAU, Craig R. (US) (73) MERCK SHARP & DOHME LLC, 126 East Lincoln Avenue, RAHWAY, New Jersey 070650907 (US) (74) Cabinet BONNY & ASSOCIÉS, LAW FIRM, B.P. 35349, YAOUNDE (CM). (57) The present invention provides a compound selected from : Compound (A) Compound (B) Compound (C)
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