BOPI 06 BR/2023 REPERTOIRE NUMERIQUE 40 (74) S.C.P AKKUM, AKKUM & Associates, n° 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo, B.P. 4966, YAOUNDE (CM). (57) The present disclosure relates, in part, to antibodies, and antigen-binding fragments thereof, that can bind to the antigenic loop region of hepatitis B surface antigen (HBsAg) and,optionally, can neutralize infection hepatitis B virus (HBV), and further optionally, of hepatitis delta virus (HDV). Presently disclosed antibodies and antigen-binding fragments have advantageous production characteristics, such as reduced formation of aggregates and/or improved production titer in transformed host cells, as compared to a reference antibody or antigenbinding fragment. The present disclosure also relates to to fusion proteins that comprise an antigen-binding fragment, and to nucleic acids that encode and cells that produce such antibodies, antigen-binding fragments, and fusion proteins. In addition, the present disclosure relates to the use of the antibodies, antigenbinding fragments, fusion proteins, and related polynucleotides, vectors, host cells, and compositions of the present disclosure in the diagnosis, prophylaxis and treatment of hepatitis B and hepatitis D. Also provided are combination therapies comprising (i) an antibody or antigenbinding fragment and (ii) an agent that is an inhibitor of HBV gene expression and/or that reduces HBV antigenic load. Fig. 19 Consulter le mémoire ________________________________________ (11) 21026 (51) C01B 32/30 (2018.01); C10L 5/40 (2018.01) (21) 1202200545 (22) 22/12/2022 (54) Charbon écologique à base de coques de café, cabosses de cacao, fibres de noix de palme et son procédé d'obtention. (72) MOUIL ENANO EMBON (CM) et MOUIL PONOMACK MAPOKO (CM)
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