BOPI 07 BR/2023 REPERTOIRE NUMERIQUE 26 (21) 1202200442 - PCT/US2021/029574 (22) 28/04/2021 (30) US n° 63/016,891 du 28/04/2020; US n° 63/127,774 du 18/12/2020 (54) Cycloalkyl pyrimidines as ferroportin inhibitors. (72) LI, Zhe (US); XU, Qing (US); ALT, Carsten (US); NILAR, Shahul (US); RADEMACHER, Peter Michael (US) et YEE, Calvin Wesley (US) (73) GLOBAL BLOOD THERAPEUTICS, INC., 181 Oyster Point Blvd., SOUTH SAN FRANCISCO, California 94080 (US) (74) S.C.P AKKUM, AKKUM & Associates, n° 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo, B.P. 4966, YAOUNDE (CM). (57) The subject matter described herein is directed to ferroportin inhibitor compounds of Formula I or I' and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries. Compounds of Formula I Compounds of Formula I’ Consulter le mémoire ________________________________________ (11) 21053 (51) A01N 57/20 (2018.01) ; C07K 14/415 (2018.01) (21) 1202200443 - PCT/US2021/028920 (22) 23/04/2021 (30) US n° 63/016,904 du 28/04/2020 (54) Plant regulatory elements and uses thereof. (72) FLASINSKI, Stanislaw (US) et CHITTOOR, Jaishree, M. (US) (73) MONSANTO TECHNOLOGY LLC, 800 North Lindbergh Boulevard, ST LOUIS, MO 63167 (US) (74) S.C.P AKKUM, AKKUM & Associates, n° 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo, B.P. 4966, YAOUNDE (CM). (57) The invention provides recombinant DNA molecules and constructs, as well as their nucleotide sequences, useful for modulating gene expression in plants. The invention also provides transgenic plants, plant cells, plant parts, and seeds comprising the recombinant DNA molecules operably linked to heterologous transcribable DNA molecules, as are methods of their use.
RkJQdWJsaXNoZXIy MTM1NDc3MA==