BOPI 07 BR/2023 REPERTOIRE NUMERIQUE 39 (11) 21071 (51) A61K 38/17 (2018.01); A61K 38/18 (2018.01); A61K 39/00 (2018.01); A61K 48/00 (2018.01) ; A61P 31/12 (2018.01) (21) 1202200495 - PCT/IB2021/056179 (22) 09/07/2021 (30) ZA n° 2020/04008 du 09/07/2020; ZA n° 2020/03850 du 09/07/2020 (54) Compositions and methods useful for the prevention and/or treatment of disease in mammals. (72) SMIT, Michelle Olga Patricia Giesteira Da Silva (ZA) (73) VIRO-GEN (PTY) LTD, 313 Cliff Avenue, Waterkloof Ridge X2, PRETORIA, Gauteng 0181 (ZA) (74) SCP ATANGA IP, 2nd Floor Tayou Bldg, Fokou Douche Akwa, P.O. Box 4663, DOUALA (CM). (57) Novel methods and pharmaceutical composition or medicaments are described for protecting a subject against, or treating a subject suffering from, disease characterised 5 by viral infection and/or diseases associated with immune system disorder and/or viral cancers, by raising the levels of Ksp37 in the blood plasma of the subject to a therapeutically effective concentration level. According to the invention, a therapeutically effective amount of one or more of; a clinically modified or genetically engineered Ksp37 protein and/or proteins having a molecular weight in the range 10 ranging from 24 kDa to 45 kDa, and/or a vector encoded with a KSP37 gene which will translate to a Ksp37 protein and/or proteins having a molecular weight in the range ranging from 24 kDa to 45 kDa, and/or a polar compound are administered to a subject. Graphique p. 45 Consulter le mémoire ________________________________________ (11) 21072 (51) A61K 39/00 (2018.01); A61K 39/135 (2018.01); A61P 31/12 (2018.01); C07K 14/005 (2018.01) ; C12N 7/00 (2018.01) (21) 1202200496 - PCT/US2021/034282 (22) 26/05/2021 (30) US n° 63/030,431 du 27/05/2020; US n° 17/330,545 du 26/05/2021 (54) Live attenuated strains of foot and mouth disease modified by deoptimization and uses thereof. (72) DE LOS SANTOS, Teresa B. (US); RIEDER, Aida E. (US); DIAZ-SAN SEGUNDO, Fayna C. (US); KLOC, Anna (US); COLEMAN, John R. (US); MUELLER, Steffen (US) et MEDINA, Gisselle N. (US) (73) 1-THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE, 1400 Independence Ave. S. W., WASHINGTON,District of Columbia 20250 (US) et
RkJQdWJsaXNoZXIy MTM1NDc3MA==