BOPI 07 BR/2023 REPERTOIRE NUMERIQUE 43 (21) 1202200509 - PCT/RU2021/000238 (22) 02/06/2021 (30) RU n° 2020118148 du 02/06/2020 (54) Codon-optimized nucleic acid that encodes SMN1 protein, and use thereof (72) MOROZOV, Dmitry Valentinovich (RU); MADERA, Dmitriy Aleksandrovich (RU); GERSHOVICH, Pavel Mikhailovich (RU); VESELOVA, Anna Sergeevna (RU); SHUGAEVA, Tatiana Evgenievna (RU); LOMUNOVA, Maria Andreevna (RU) et SHKLIAEVA, Margarita Aleksandrovna (RU) (73) JOINT STOCK COMPANY "BIOCAD", 198515, SAINT PETERSBURG, vn. ter. g. poselok Strelna, p. Strelna, ul. Svyazi, d. 38, str. 1, pomeshch. 89, Russian Federation (RU) (74) Cabinet ISIS CONSEILS (SCP), Bastos, rue 1.862, face de l'Agence Turque de Coopération et de Coordination, B.P. 15067, YAOUNDE (CM). (57) The present application relates to the fields of genetics, gene therapy, and molecular biology. More specifically, the present invention relates to an isolated codon-optimized nucleic acid that encodes the SMN1 protein (survival motor neuron protein), an expression cassette and a vector based thereon, as well as an AAV9 (adenoassociated virus serotype 9)-based recombinant virus for increasing the expression of the SMN1 gene in target cells, and use thereof. Fig. 1 Consulter le mémoire ________________________________________ (11) 21076 (51) E21B 17/02 (2018.01) ; E21B 17/042 (2018.01) (21) 1202200518 - PCT/EP2021/067808 (22) 29/06/2021 (30) EP n° 20183128.6 du 30/06/2020 (54) Thread clearance. (72) HAMMARGREN, John (SE) (73) SANDVIK MINING AND CONSTRUCTION TOOLS AB, 81181 SANDVIKEN (SE) (74) S.C.P AKKUM, AKKUM & Associates, n° 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo, B.P. 4966, YAOUNDE (CM). (57) A female portion to form part of a thread joint for a percussive drilling tool comprising a mounting sleeve having an axial end, wherein the mounting
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