BOPI 01 BR/2024 REPERTOIRE NUMERIQUE 32 (57) The present invention is directed to long lasting topical liquid hydroalcoholic biocide compositions characterised by contents of cannabidiol (CBD) and a CBD solubilizing agent, preferably propylene glycol. ________________________________________ (11) 21365 Consulter le mémoire (51) A61K 35/761 (2018.01); A61P 21/00 (2018.01); C12N 15/113 (2018.01); C12N 15/12 (2018.01); C12N 15/861 (2018.01) ; C12N 7/01 (2018.01) (21) 1202300302 - PCT/RU2022/000025 (22) 28/01/2022 (30) RU n° 2021102051 du 29/01/2021 (54) Synergistic effect of SMN1 and MIR-23A in treating spinal muscular atrophy. (72) MOROZOV, Dmitry Valentinovich (RU); MADERA, Dmitriy Aleksandrovich (RU); GERSHOVICH, Pavel Mikhailovich (RU); VESELOVA, Anna Sergeevna (RU) et SIUTKIN, Aleksei Sergeevich (RU) (73) JOINT STOCK COMPANY ‘‘BIOCAD’’, ul. Svyazi, d. 38, str. 1, Pomeshch. 89, Intracity Municipality the Settlement of Strelna, SAINT PETERSBURG 198515, Russian Federation (RU) (74) Cabinet ISIS CONSEILS (SCP), BASTOS, Rue 1.862 B.P. 15067, YAOUNDE (CM). (57) The present application relates to the fields of biotechnology, virology, genetics, and molecular biology. More specifically, the present invention relates to an isolated nucleic acid for producing a gene therapy viral product, said isolated nucleic acid comprising a nucleic acid that encodes the SMN1 protein having the amino acid sequence of SEQ ID NO: 1, and a nucleic acid that encodes the microRNA miR-23a, an expression cassette and a vector based thereon, as well as an AAV9based recombinant virus for expressing the SMN1 gene in target cells, a pharmaceutical composition that includes said recombinant virus, and various uses of the above recombinant virus and the above composition. Figure 5 ________________________________________ (11) 21366 Consulter le mémoire (51) F24S 25/30 (2018.01); F24S 25/40 (2018.01); H02S 20/23 (2018.01) ; H02S 20/25 (2018.01) (21) 1202300307 (22) 03/08/2023 (30) DE n° 10 2022 119 701.8 du 05/08/2022 (54) Panel element, in particular roof tile with support for solar cell. (72) Dr. Sonja Sagmeister- Brandner (AT) (73) Dr. Sonja Sagmeister- Brandner, Diabelligasse 1/1/6, 1130 VIENNA (AT) (74) Martin FOUDA, Avenue de Nsimeyong, Rue 7.415 - No 794 et 806, YAOUNDE 3 (CM).
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