BOPI 01 BR/2024 REPERTOIRE NUMERIQUE 34 (72) BIDI, Bülent (TR) et OLGUN, Abdullah (TR) (73) ARGERON MEDİKAL ARAŞTIRMA SANAYİ VE TİCARET ANONİM ŞİRKETİ, Altinkale Mahallesi Akdeniz Bulvari No : 191, Döşemealti, ANTALYA (TR) (74) S.C.P. AKKUM AKKUM & Associates, No. 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo B.P. 4966, YAOUNDE (CM). (57) The invention relates to the deamidation rate measurement kit, which includes a stock solution of the compound Boc-Asn-Gly-OEt in deionized/distilled water, and a stock solution of the compound Boc-Asp-Gly-OEt in deionized/distilled water. Fig. 1 ________________________________________ (11) 21369 Consulter le mémoire (51) A61K 35/761 (2018.01); A61K 48/00 (2018.01); C07K 14/075 (2018.01); C12N 15/63 (2018.01); C12N 15/67 (2018.01); C12N 15/861 (2018.01) ; C12N 7/00 (2018.01) (21) 1202300359 - PCT/RU2022/050073 (22) 05/03/2022 (30) RU n° 2021105703 du 05/03/2021 (54) Codon-optimized nucleic acid encoding the fix protein. (72) MOROZOV, Dmitry Valentinovich (RU); GERSHOVICH, Pavel Mikhailovich (RU); SHUGAEVA, Tatiana Evgenievna (RU); PROKOFYEV, Alexander Vladimirovich (RU); STRELKOVA, Anna Nikolaevna (RU) et SPIRINA, Natalia Aleksandrovna (RU) (73) JOINT STOCK COMPANY ‘‘BIOCAD’’, 198515, SAINT-PETERSBURG, vn. ter. g. poselok Strelna, p. Strelna, ul. Svyazi, d. 38, str. 1, pomeshch. 89, Russian Federation (RU) (74) Cabinet ISIS CONSEILS (SCP), Bastos, Rue 1.862, B.P. 15067, YAOUNDE (CM). (57) The present application relates to the fields of genetics, gene therapy, and molecular biology. More specifically, the present invention relates to an isolated codon-optimized nucleic acid that encodes the FIX (coagulation factor IX) protein, an expression cassette and a vector based thereon, as well as an AAV5 (adeno-associated virus serotype 5)-based recombinant virus for increasing the expression of the FIX gene in target cells, and use thereof.
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