BOPI 01 BR/2024 REPERTOIRE NUMERIQUE 38 (54) RNAI agents for inhibiting expression of receptor for advanced glycation end-products, compositions thereof, and methods of use. (72) NICHOLAS, Anthony (US); BUSH, Erik, W. (US) et KASAHARA, David, Itiro (US) (73) ARROWHEAD PHARMACEUTICALS, INC., 177 East Colorado Boulevard, Suite 700, PASADENA, CA 91105 (US) (74) S.C.P. AKKUM AKKUM & Associates, No. 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo B.P. 4966, YAOUNDE (CM). (57) Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a Receptor for Advanced Glycation End-products (AGER or RAGE) gene. The RAGE RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of an AGER gene. Pharmaceutical compositions that include one or more RAGE RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described RAGE RNAi agents to pulmonary cells, in vivo, provides for inhibition of AGER gene expression and a reduction in membrane RAGE activity, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including pulmonary inflammation diseases such as severe asthma. ________________________________________ (11) 21375 Consulter le mémoire (51) E02F 9/28 (2018.01) (21) 1202300413 - PCT/US2022/025109 (22) 15/04/2022 (54) Wear assembly. (72) WOOD, Clinton, A. (US); LEEDHAM, Cameron, R. (US); SNYDER, Christopher, D (US) et GREWELL, Christopher, E. (US) (73) ESCO GROUP LLC, 2141 NW 25th Avenue, PORTLAND, OR 97210-2578 (US) (74) S.C.P. AKKUM AKKUM & Associates, No. 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo B.P. 4966, YAOUNDE (CM). (57) A wear assembly for earth working equipment including a wear member including an exterior surface, an opening to receive a separable component, and a hole extending from the
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