BOPI 01 BR/2024 REPERTOIRE NUMERIQUE 40 Fig. 1 ________________________________________ (11) 21377 Consulter le mémoire (51) A01K 61/73 (2018.01) (21) 1202300416 - PCT/IB2021/000264 (22) 06/04/2021 (30) (54) Artificial reef. (72) BASSERES, Anne (FR); BLANC, Philippe (FR); LAPINSKI, Matthieu (FR); DALLE, Julien (FR); MUSNIER, Alexandre (FR); PERROT, Martin (FR) et CAPET, Joffrey (FR) (73) 1-TOTALENERGIES ONETECH, La Défense 6, 2 Place Jean Millier, 92400 COURBEVOIE (FR) et 2-SEABOOST, 889 rue de la Vieille Poste, 34000 Montpellier (FR) (74) S.C.P. AKKUM AKKUM & Associates, No. 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo B.P. 4966, YAOUNDE (CM). (57) The invention relates to an artificial reef (1) comprising: a base plate (2) having an upper surface (2a) and a lower surface; a central pole (3) having an upper extremity (3a) and a lower extremity (3b), the central pole (3) being connected perpendicularly to the upper surface (2a) of the base plate (2) by its lower extremity (3b); a peripheral structure fixed to the upper surface (2a) of the base plate (2) and disposed around the central pole (3), said peripheral structure being formed of a plurality of interconnected units (4) having different orientations. The invention also relates to a method for the restoration of coral reefs by using said artificial reef (1). Figure 1 ________________________________________ (11) 21378 Consulter le mémoire (51) A61K 31/282 (2018.01); A61K 31/337 (2018.01); A61K 39/395 (2018.01); A61K 45/06 (2018.01) ; A61P 35/00 (2018.01) (21) 1202300418 - PCT/RU2022/050122 (22) 08/04/2022 (30) RU n° 2021109765 du 08/04/2021 (54) Malignant neoplasis treatment using PD-1 antibody combination. (72) MOROZOV, Dmitry Valentinovich (RU); SHUSTOVA, Mariia Stanislavovna (RU); FOGT, Sergei Nikolaevich (RU) et KRYUKOV, Fedor Borisovich (RU) (73) JOINT STOCK COMPANY ‘‘BIOCAD’’, pomeshch. 89, str. 1, d. 38, ul. Svyazi, the Settlement of Strelna, Intracity Municipality the Settlement of Strelna, SAINT PETERSBURG, 198515, Russian Federation (RU) (74) Cabinet ISIS CONSEILS (SCP), Bastos, Rue 1.862, B.P. 15067, YAOUNDE (CM). (57) The present invention relates to the use of antibody to PD-1, in particular prolgolimab, in
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