BOPI 11 BR/2024 REPERTOIRE NUMERIQUE 25 (30) CN n° PCT/CN2021/130284 du 12/11/2021 et CN n° PCT/CN2022/123821 du 08/10/2022 (54) Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof. (72) WU Jianping (CN); QIN Luoheng (CN) et LIU Jinxin (CN) (73) INSILICO MEDICINE IP LIMITED, 26th Floor, Three Exchange Square, 8 Connaught Place Central, HONG KONG (CN) (74) Cabinet CAZENAVE SARL, B.P. 500, YAOUNDE (CM). (57) The disclosure provides for small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. The disclosure further provides methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer. Formula I ________________________________________ (11) 21707 Consulter le mémoire (51) A61K 31/415 (2023.01); A61K 31/44 (2023.01); A61K 31/505 (2023.01); A61K 31/55 (2023.01); A61P 35/00 (2023.01); C07D 471/04 (2023.01) ; C07D 487/04 (2023.01) (21) 1202400180 - PCT/CN2022/131293 (22) 11/11/2022 (30) CN n° PCT/CN2021/130290 du 12/11/2021 et CN n° PCT/CN2022/123827 du 08/10/2022 (54) Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof. (72) QIN Luoheng (CN); LIU Jinxin (CN) et WU Jianping (CN) (73) INSILICO MEDICINE IP LIMITED, 26th Floor, Three Exchange Square, 8 Connaught Place Central, HONG KONG, China (CN) (74) Cabinet CAZENAVE SARL, B.P. 500, YAOUNDE (CM). (57) The disclosure provides for small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. The disclosure further provides methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer. Formula IVa ________________________________________ (11) 21708 Consulter le mémoire (51) A61K 31/519 (2023.01); C07D 273/00 (2023.01); C07D 291/08 (2023.01) ; C07D 417/14 (2023.01) (21) 1202400181 - PCT/CN2022/131359 (22) 11/11/2022 (30) CN n° PCT/CN2021/130289 du 12/11/2021 et CN n° PCT/CN2022/123806 du 08/10/2022 (54) Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof.
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