BOPI 11 BR/2024 REPERTOIRE NUMERIQUE 27 Planche Unique - Fig. 1 ________________________________________ (11) 21711 Consulter le mémoire (51) A61K 31/713 (2023.01); A61P 1/16 (2023.01) ; C12N 15/113 (2023.01) (21) 1202400201 - PCT/CN2022/134879 (22) 29/11/2022 (30) CN n° PCT/CN2021/133837 du 29/11/2021 (54) Composition and method for inhibiting expression of hepatitis B virus (HBV) protein. (72) SHU, Dongxu (CN) et SHAO, Pengcheng Patrick (US) (73) SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD., 337 Shahe Road, J2026, Room 1_203, Jiangqiao Town, Jaiding District, SHANGHAI 201803 (CN) (74) S.C.P AKKUM, AKKUM & Associates, No. 1777, rue 6.261, Yaoundé 2, Auditorium Jean Paul II boulevard, Face Brigade de Gendarmerie, Mbankolo, B.P. 4966, YAOUNDE (CM). (57) Compositions and methods useful to reduce expression of one or more hepatitis B viral (HBV) genes and for treatment of HBV-associated diseases and conditions are provided. Provided are HBV dsRNA agents, and compositions comprising HBV dsRNA agents that can be used to reduce HBV expression in cells and subjects. Planche Unique - Fig. 1 ________________________________________ (11) 21712 Consulter le mémoire
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