BOPI 11 BR/2024 REPERTOIRE NUMERIQUE 34 (54) Compositions and methods for inhibiting expression of Prekallikrein (PKK) protein. (72) SHU, Dongxu (CN); XIA, Shiwei (CN) et SHAO, Pengcheng Patrick (CN) (73) SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD., 337 Shahe Road, J2026, Room 1_203, Jiangqiao Town, Jiading District, SHANGHAI 201803 (CN) (74) ALEMBONG OSWALD AMIN, S/C Von Seidels Cameroon Sarl, EasyOffice Building, Centre de l'Artisanat, Carrefour Intendance, B.P. 30188, YAOUNDE (CM). (57) Compositions and methods useful to reduce expression of a kallikrein Bl (KLKB1 or PKK) gene and for treatment of PKK-associated diseases and conditions are provided. Provided are PKK dsRNA agents, and compositions comprising PKK dsRNA agents that can be used to reduce PKK expression in cells and subjects. Fig. 2 ________________________________________ (11) 21723 Consulter le mémoire (51) A61F 6/08 (2023.01); A61K 31/505 (2023.01); A61K 31/57 (2023.01); A61K 47/14 (2023.01) ; A61P 15/18 (2023.01) (21) 1202400255 - PCT/EP2023/011131 (22) 19/01/2023 (30) US n° 63/301,588 du 21/01/2022 (54) Combination therapy intravaginal rings. (72) KLEINBECK, Kyle, Robert (US); SPENCE, Patrick, Lawrence (US); NUTTALL, Jeremy, Peter (US); HANSRAJ, Bashir, Ramzanali (US); DANGI, Bindi, Ajit (US); DE GRAAFF, Wouter (SE); FETHERSTON, Susan (SE) et HENDRIKUS VAN LAARHOVEN, Johannes, Antonius (SE) (73) THE POPULATION COUNCIL, INC., One Dag Hammarskjold Plaza, NEW YORK, NY 10017 (US) (74) S.C.P AKKUM, AKKUM & Associates, No. 1777, rue 6.261, Yaoundé 2, Auditorium Jean Paul II boulevard, Face Brigade de Gendarmerie, Mbankolo, B.P. 4966, YAOUNDE (CM). (57) The present disclosure provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of dapivirine in combination with either an antimicrobial compound or a contraceptive to a human. The present disclosure also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, methods of preventing unintended pregnancy in a female human, and methods of preparing intravaginal rings.
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