BOPI 02 BR/2024 REPERTOIRE NUMERIQUE 40 (73) ARROWHEAD PHARMACEUTICALS, INC., 177 East Colorado Boulevard, Suite 700, PASADENA, CA 91105 (US) (74) S.C.P. AKKUM AKKUM & Associates, No. 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo B.P. 4966, YAOUNDE (CM). (57) Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a Mucin SAC (MUC5AC) gene. The MUC5AC RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of an MUC5AC gene. Pharmaceutical compositions that include one or more MUC5AC RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described MUC5AC RNAi agents to pulmonary epithelial cells, in vivo, provides for inhibition of MUC5AC gene expression and a reduction in MUC5AC production, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including mucoobstructive lung disease such as severe asthma and various cancers. ________________________________________ (11) 21428 Consulter le mémoire (51) B03D 1/14 (2018.01) ; B03D 1/16 (2018.01) (21) 1202300474 - PCT/FI2022/050368 (22) 27/05/2022 (30) EP n° 21176490.7 du 28/05/2021 (54) Rotor of gas dispersion arrangement. (72) LUUKKONEN, Matti (FI) et HÄMÄLÄINEN, Timo (FI) (73) METSO FINLAND OY, Rauhalanpuisto 9, 02230 ESPOO (FI) (74) S.C.P. AKKUM AKKUM & Associates, No. 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo B.P. 4966, YAOUNDE (CM). (57) A rotor (100) of a gas dispersion arrangement, comprising a cover disc (1), air slots (2) arranged to protrude away from the cover disc (1), the air slots (2) defining an interior space (3) in the interior of the rotor, an air channel (4) connected to the air slot (2) for supplying air to be dispensed in slurry, and slurry slots (5) arranged between and an alternating way with the air slots (2) around the interior space (3). The slurry slots (5) are in fluid communication with the interior space (3), and radially extending blades (6) arranged for separating the air slot (2) from adjacent slurry slots (5). The cover disc (1) comprises at least one through-hole (7) extending from an upper surface (8) of the cover disc to at least one of the slurry slots (5) . ________________________________________ (11) 21429 Consulter le mémoire (51) E21B 17/042 (2018.01)
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