BOPI 04 BR/2024 REPERTOIRE NUMERIQUE 11 (11) 21481 Consulter le mémoire (51) A61K 31/4015 (2018.01); A61K 31/4025 (2018.01); A61P 31/14 (2018.01); C07D 207/267 (2018.01); C07D 401/12 (2018.01); C07D 403/12 (2018.01); C07D 403/14 (2018.01) ; C07D 497/04 (2018.01) (21) 1202200127 - PCT/IB2021/057281 (22) 06/08/2021 (30) US n° 63/073,982 du 03/09/2020; US n° 63/143,435 du 29/01/2021; US n° 63/170,158 du 02/04/2021; US n° 63/194,241 du 28/05/2021 (54) Nitrile-containing antiviral compounds. (72) PETTERSSON, Martin Youngjin (US); VERHOEST, Patrick Robert (US); TUTTLE, Jamison Bryce (US); OWEN, Dafydd Rhys (US); YANG, Xiaojing (US); REESE, Matthew Richard (US); SAMMONS, Matthew Forrest (US); WEI, Liuqing (US) et YANG, Qingyi (US) (73) PFIZER INC., 235 East 42nd Street, NEW YORK, New York 10017 (US) (74) S.C.P. AKKUM AKKUM & Associates, No. 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo B.P. 4966, YAOUNDE (CM). (57) The invention relates to compounds of ‘‘Formula I’’ wherein R, R1, R2, R3, p, q and q' are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds. Formula I & Fig. 1 ________________________________________ (11) 21482 Consulter le mémoire (51) E21B 23/14 (2018.01) (21) 1202200503 - PCT/NO2021/050131 (22) 25/05/2021 (30) NO n° 20200652 du 03/06/2020 (54) Pulling tool. (72) AKSELBERG, Frank Ove (NO) (73) WELL INNOVATION AS, Koppholen 19, 4213 SANDNES (NO)
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