BOPI 04 BR/2024 REPERTOIRE NUMERIQUE 29 (54) Recovery of metals from metallic or metalbearing materials. (72) PRETORIUS, Gerard (ZA) (73) AFRICAN RAINBOW MINERALS LIMITED, ARM House, 29 Impala Road, Chislehurston, 2196 SANDTON (ZA) (74) S.C.P. AKKUM AKKUM & Associates, No. 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo B.P. 4966, YAOUNDE (CM). (57) A method of treating a metallic or metal-bearing material includes, in an oxidative or reductive digestion step, contacting the metallic or metalbearing material with a reagent selected from ferric chloride (FeCI3), hydrochloric acid (HCI), and a combination thereof, thus producing a ferrous chloride (FeCI2) solution. Fig. 1 ________________________________________ (11) 21508 Consulter le mémoire (51) A61K 31/45 (2018.01); A61P 35/00 (2018.01); C07D 401/14 (2018.01); C07D 471/04 (2018.01) ; C07D 487/10 (2018.01) (21) 1202300421 - PCT/US2022/025041 (22) 15/04/2022 (30) US n° 63/175,678 du 16/04/2021 (54) Modulators of BCL6 proteolysis and associated methods of use. (72) DONG, Hanqing (US); SNYDER, Lawrence B. (US); WANG, Jing (US); ZHANG, Wei (US); SHERMAN, Dan (US) et BERLIN , Michael (US) (73) ARVINAS OPERATIONS, INC., 5 Science Park, NEW HAVEN, Connecticut 06511 (US) (74) S.C.P. AKKUM AKKUM & Associates, No. 1777, Rue 6.261, Auditorium Jean Paul II, Quartier Mbankolo B.P. 4966, YAOUNDE (CM). (57) Bifunctional compounds, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a cereblon ligand that binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
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