BOPI 07 BR/2024 REPERTOIRE NUMERIQUE 14 corresponding, inverse topographical pattern (8) on the filtrate vat (4). The topographical patterns (3, 8) guide the filtrate flow towards a filtrate outlet (7) and reduces the formation of vortices and turbulent flow of the filtrate, hence increasing the filtrate flow rate through the vat. Simultaneous, the topographical patterns (3, 8) improve secure attachment of the grid (1) onto the vat (4), thereby allowing increased travel speed of the filter medium during advancement thereof. As a result, the cycle time of a filtration process may be reduced, and consequently, the overall capacity of the associated filter press is increased. A filtrate vat assembly and a vertical filter are also disclosed. Fig .1 (11) 21576 Consulter le mémoire (51) A61K 31/519 (2018.01); A61P 43/00 (2018.01) ; C07D 515/04 (2018.01) (21) 1202300153 - PCT/US2021/053860 (22) 06/10/2021 (30) US n° 63/088,935 du 07/10/2020 (54) Modulators of cystic fibrosis transmembrane conductance regulator. (72) ARUMUGAM, Vijayalaksmi (US); KRENITSKY, Paul (US); MILLER, Mark Thomas (US); CLEVELAND, Thomas (US); COON, Timothy Richard (US); FRIEMAN, Bryan A. (US); MELILLO, Vito (US); MCCARTNEY, Jason (US); SILINA, Alina (US); UY, Johnny (US); ZHOU, Jinglan (US); HADIDA RUAH, Sara Sabina (US); KHATUYA, Haripada (US); ABELA, Alexander Russell (US); PARASELLI, Prasuna (US); ANDERSON, Corey Don (US); GULEVICH, Anton V. (US); PIERRE, Fabrice (US); ABRAHAM, Sunny (US); CHAU, Jaclyn (US); CLEMENS, Jeremy (US); DWIGHT, Timothy A. (US); FANNING, Lev Tyler Dewey (US); VALDEZ, Lino (US); ISHIHARA, Yoshihiro (US); TRAN, Joe A. (US) et GROOTENHUIS, Peter (deceased) (US) (73) Vertex Pharmaceuticals Incorporated, 50 Northern Avenue, BOSTON, Massachusetts 02210 (US) (74) Cabinet Spoor & Fisher Inc. Ngwafor & Partners, The House of Gideon, Golf/Bastos Quater, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57)
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